Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADC_R4_z_3	tier2_gs	1.56e-01	9.43e-02	6.18e-02	5.05e-04
tier2_gs	ADC_R4_z_3	1.78e-01	1.42e-02	3.91e-05	6.96e-03



Evaluating how well ADC_R4_z_3 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC_R4_z_3	tier2_gs	0.69	2.18	2.71	2.28	4.07
tier2_gs	ADC_R4_z_3	0.57	2.43	3.23	1.99	3.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC_R4_z_3	tier2_gs	0.01	3.86	6.26	4.57	6.28
tier2_gs	ADC_R4_z_3	0.01	3.29	2.99	3.35	2.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADC_R4_z_3	127	122	AP001781.2;ZNF511-PRAP1;AC005779.2;PRAMEF15;LINC02210-CRHR1
tier2_gs	46	43	IGH;TNSF13;TNSF12