Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADC_R4_z_3_5	tier2_gs	1.55e-01	8.03e-02	9.88e-03	5.45e-04
tier2_gs	ADC_R4_z_3_5	1.51e-01	9.51e-02	1.31e-02	2.51e-02



Evaluating how well ADC_R4_z_3_5 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC_R4_z_3_5	tier2_gs	0.68	2.06	2.56	2.13	4.18
tier2_gs	ADC_R4_z_3_5	0.63	1.84	1.79	1.34	2.92

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC_R4_z_3_5	tier2_gs	0.01	3.88	6.03	3.93	3.98
tier2_gs	ADC_R4_z_3_5	0.00	2.94	2.75	3.01	2.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADC_R4_z_3_5	33	31	PRAMEF15;AC005779.2
tier2_gs	46	43	TNSF12;IGH;TNSF13