Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
selected2_R4_z_3_5	tier2_gs	1.58e-01	4.95e-02	4.14e-02	6.02e-03
tier2_gs	selected2_R4_z_3_5	4.22e-02	1.90e-02	1.04e-03	1.02e-02



Evaluating how well selected2_R4_z_3_5 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
selected2_R4_z_3_5	tier2_gs	0.66	1.82	2.91	2.14	3.57
tier2_gs	selected2_R4_z_3_5	0.61	2.58	2.44	2.10	2.64

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
selected2_R4_z_3_5	tier2_gs	0.00	1.63	4.65	2.47	3.82
tier2_gs	selected2_R4_z_3_5	0.00	0.57	2.47	2.39	2.86

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
selected2_R4_z_3_5	56	53	TMEM191C;PRAMEF15;AC005779.2
tier2_gs	46	43	TNSF12;IGH;TNSF13