Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	tier1_31	1.56e-05	8.84e-04	6.84e-06	8.09e-07
tier1_31 Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_43	1.47e-01	4.04e-01	3.83e-01	2.34e-01
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	tier1_31 Exclusive	3.18e-05	3.67e-04	8.00e-06	2.23e-06
tier1_31 Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	7.98e-02	8.12e-01	8.35e-01	4.64e-01
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	Overlap	4.32e-01	1.41e-01	4.15e-01	1.70e-01
tier1_31 Exclusive	Overlap	4.36e-07	4.36e-07	1.74e-06	4.36e-06
Overlap	Exclusives	2.18e-06	4.33e-06	1.17e-09	4.33e-06



Evaluating how well EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	tier1_31	0.79	3.50	4.71	3.16	5.66
tier1_31 Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_43	0.57	0.57	0.82	0.72	1.85
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	tier1_31 Exclusive	0.79	4.81	5.43	3.16	5.40
tier1_31 Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	0.54	-0.32	0.28	-0.08	0.84
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	Overlap	0.78	1.19	1.55	0.99	1.72
tier1_31 Exclusive	Overlap	1.00	3.03	2.97	2.50	2.86
Overlap	Exclusives	0.70	4.94	5.58	3.76	6.19

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	tier1_31	0.00	3.62	1.99	1.60	2.29
tier1_31 Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_43	0.01	3.21	20.57	3.48	3.47
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	tier1_31 Exclusive	0.00	5.57	1.46	3.06	4.09
tier1_31 Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	0.00	1.42	4.10	3.70	2.34
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	Overlap	0.00	0.31	0.09	0.19	0.19
tier1_31 Exclusive	Overlap	0.04	119.85	180.02	76.90	59.43
Overlap	Exclusives	0.04	15.71	84.66	53.28	15.10

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	40	40	
tier1_31 Exclusive	28	27	MS4A
Overlap	3	3