Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R4_103 Exclusive	tier1_31	1.46e-07	1.88e-06	5.48e-07	2.08e-08
tier1_31 Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_103	5.21e-01	3.56e-01	1.15e-01	1.02e-01
EUR_PHC_cog_last_visit_wellderly_impaired_R4_103 Exclusive	tier1_31 Exclusive	2.19e-07	1.79e-06	1.79e-06	3.62e-08
tier1_31 Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_103 Exclusive	2.89e-01	4.73e-01	2.79e-01	1.39e-01
EUR_PHC_cog_last_visit_wellderly_impaired_R4_103 Exclusive	Overlap	7.89e-01	7.89e-01	8.01e-01	3.42e-01
tier1_31 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	8.71e-06
Overlap	Exclusives	7.20e-05	3.22e-05	1.65e-12	2.12e-05



Evaluating how well EUR_PHC_cog_last_visit_wellderly_impaired_R4_103 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R4_103 Exclusive	tier1_31	0.77	3.25	4.21	2.75	5.10
tier1_31 Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_103	0.56	1.45	1.84	1.71	2.26
EUR_PHC_cog_last_visit_wellderly_impaired_R4_103 Exclusive	tier1_31 Exclusive	0.77	3.39	4.27	2.88	4.88
tier1_31 Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_103 Exclusive	0.55	0.75	1.44	1.20	2.05
EUR_PHC_cog_last_visit_wellderly_impaired_R4_103 Exclusive	Overlap	0.75	1.00	0.37	0.75	1.48
tier1_31 Exclusive	Overlap	1.00	2.62	2.85	2.84	2.97
Overlap	Exclusives	0.65	3.86	6.39	3.94	5.95

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R4_103 Exclusive	tier1_31	0.00	4.04	5.03	3.17	2.41
tier1_31 Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_103	0.01	4.64	3.17	11.94	9.18
EUR_PHC_cog_last_visit_wellderly_impaired_R4_103 Exclusive	tier1_31 Exclusive	0.00	6.24	6.23	2.32	7.00
tier1_31 Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_103 Exclusive	0.01	2.37	1.86	3.29	3.37
EUR_PHC_cog_last_visit_wellderly_impaired_R4_103 Exclusive	Overlap	0.00	10.95	3.15	6.91	5.35
tier1_31 Exclusive	Overlap	0.04	121.75	194.40	134.04	17.93
Overlap	Exclusives	0.03	14.70	16.41	21.64	32.49

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_wellderly_impaired_R4_103 Exclusive	100	99	TRIM39-RPP21
tier1_31 Exclusive	28	27	MS4A
Overlap	3	3