Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R2_196_geneage Exclusive	agegene_human	2.03e-01	1.12e-01	6.66e-04	3.89e-48
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_196_geneage	4.10e-02	3.22e-01	2.38e-15	1.15e-02
EUR_PHC_cog_last_visit_wellderly_impaired_R2_196_geneage Exclusive	agegene_human Exclusive	1.25e-01	7.03e-02	8.56e-04	8.23e-47
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_196_geneage Exclusive	3.69e-02	3.96e-01	7.91e-14	2.99e-02
EUR_PHC_cog_last_visit_wellderly_impaired_R2_196_geneage Exclusive	Overlap	6.14e-01	8.15e-01	3.37e-01	3.85e-02
agegene_human Exclusive	Overlap	7.15e-02	4.15e-02	5.08e-05	5.39e-04
Overlap	Exclusives	1.22e-15	1.27e-16	6.76e-75	1.30e-54



Evaluating how well EUR_PHC_cog_last_visit_wellderly_impaired_R2_196_geneage genes are linked to agegene_human genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R2_196_geneage Exclusive	agegene_human	0.78	1.21	3.25	1.51	16.20
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_196_geneage	0.56	3.23	1.82	2.52	2.77
EUR_PHC_cog_last_visit_wellderly_impaired_R2_196_geneage Exclusive	agegene_human Exclusive	0.78	1.20	2.83	1.37	18.09
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_196_geneage Exclusive	0.55	2.61	1.29	1.66	2.42
EUR_PHC_cog_last_visit_wellderly_impaired_R2_196_geneage Exclusive	Overlap	0.80	0.40	-0.21	0.47	2.48
agegene_human Exclusive	Overlap	0.93	4.59	2.78	2.70	3.56
Overlap	Exclusives	0.74	2.79	10.82	2.91	17.01

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R2_196_geneage Exclusive	agegene_human	0.06	0.01	2.93	1.08	41.74
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_196_geneage	0.02	26.71	11.71	11.06	10.16
EUR_PHC_cog_last_visit_wellderly_impaired_R2_196_geneage Exclusive	agegene_human Exclusive	0.06	0.13	3.46	0.86	48.77
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_196_geneage Exclusive	0.01	4.65	1.02	1.52	1.82
EUR_PHC_cog_last_visit_wellderly_impaired_R2_196_geneage Exclusive	Overlap	0.00	0.51	-0.12	1.71	0.74
agegene_human Exclusive	Overlap	0.17	69.70	110.49	211.36	512.56
Overlap	Exclusives	0.09	6.72	34.32	10.62	54.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_wellderly_impaired_R2_196_geneage Exclusive	190	188	RFPL2;TRIM39-RPP21
agegene_human Exclusive	301	299	TERC;TOP 1.00
Overlap	6	6