Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R2_112_geneage Exclusive	agegene_human	1.30e-03	6.37e-02	1.50e-05	6.75e-46
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_112_geneage	6.63e-03	6.13e-01	4.84e-11	1.20e-01
EUR_PHC_cog_last_visit_wellderly_impaired_R2_112_geneage Exclusive	agegene_human Exclusive	2.15e-03	3.41e-02	1.04e-05	1.03e-44
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_112_geneage Exclusive	2.57e-03	8.59e-01	2.66e-09	2.56e-01
EUR_PHC_cog_last_visit_wellderly_impaired_R2_112_geneage Exclusive	Overlap	6.33e-01	9.58e-01	5.62e-01	8.49e-02
agegene_human Exclusive	Overlap	2.75e-01	7.11e-02	7.20e-04	1.86e-03
Overlap	Exclusives	9.04e-10	4.57e-09	1.41e-91	3.60e-57



Evaluating how well EUR_PHC_cog_last_visit_wellderly_impaired_R2_112_geneage genes are linked to agegene_human genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R2_112_geneage Exclusive	agegene_human	0.77	1.76	2.36	1.50	15.17
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_112_geneage	0.56	1.46	1.58	2.30	2.49
EUR_PHC_cog_last_visit_wellderly_impaired_R2_112_geneage Exclusive	agegene_human Exclusive	0.77	1.67	2.64	1.46	15.97
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_112_geneage Exclusive	0.54	0.92	0.83	1.94	1.55
EUR_PHC_cog_last_visit_wellderly_impaired_R2_112_geneage Exclusive	Overlap	0.76	0.51	-0.07	0.26	2.07
agegene_human Exclusive	Overlap	0.92	4.63	2.75	2.45	3.06
Overlap	Exclusives	0.75	2.25	7.23	1.71	17.91

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R2_112_geneage Exclusive	agegene_human	0.05	1.13	2.45	1.26	26.83
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_112_geneage	0.01	3.31	2.59	3.40	2.94
EUR_PHC_cog_last_visit_wellderly_impaired_R2_112_geneage Exclusive	agegene_human Exclusive	0.04	1.11	2.74	1.44	25.40
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_112_geneage Exclusive	0.01	3.44	1.43	0.81	1.14
EUR_PHC_cog_last_visit_wellderly_impaired_R2_112_geneage Exclusive	Overlap	0.00	1.49	2.94	2.73	-0.03
agegene_human Exclusive	Overlap	0.00	-0.76	3.43	1.62	6.60
Overlap	Exclusives	0.06	4.49	17.66	3.86	30.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_wellderly_impaired_R2_112_geneage Exclusive	107	105	TRIM39-RPP21;RFPL2
agegene_human Exclusive	302	300	TOP 1.00;TERC
Overlap	5	5