Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R4_103_geneage Exclusive	agegene_human	6.35e-01	3.06e-01	1.47e-01	1.20e-35
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_103_geneage	1.12e-01	6.02e-01	1.42e-09	1.39e-01
EUR_PHC_cog_last_visit_wellderly_impaired_R4_103_geneage Exclusive	agegene_human Exclusive	5.47e-01	4.09e-01	1.13e-01	1.09e-34
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_103_geneage Exclusive	1.11e-01	5.81e-01	4.43e-09	2.91e-01
EUR_PHC_cog_last_visit_wellderly_impaired_R4_103_geneage Exclusive	Overlap	1.50e-01	9.28e-01	1.92e-01	3.58e-02
agegene_human Exclusive	Overlap	4.36e-07	4.24e-01	4.36e-07	2.44e-04
Overlap	Exclusives	8.66e-07	6.16e-29	3.19e-115	1.09e-93



Evaluating how well EUR_PHC_cog_last_visit_wellderly_impaired_R4_103_geneage genes are linked to agegene_human genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R4_103_geneage Exclusive	agegene_human	0.73	0.32	1.30	0.57	13.67
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_103_geneage	0.55	1.63	1.04	0.92	1.62
EUR_PHC_cog_last_visit_wellderly_impaired_R4_103_geneage Exclusive	agegene_human Exclusive	0.73	0.30	0.99	0.51	14.40
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_103_geneage Exclusive	0.53	1.24	0.89	0.66	1.35
EUR_PHC_cog_last_visit_wellderly_impaired_R4_103_geneage Exclusive	Overlap	0.89	1.54	0.39	1.40	2.42
agegene_human Exclusive	Overlap	0.99	2.92	1.41	2.17	2.67
Overlap	Exclusives	0.80	2.01	14.04	2.55	23.18

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R4_103_geneage Exclusive	agegene_human	0.04	0.06	1.98	0.34	19.01
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_103_geneage	0.01	5.32	0.82	1.99	1.88
EUR_PHC_cog_last_visit_wellderly_impaired_R4_103_geneage Exclusive	agegene_human Exclusive	0.03	0.03	1.73	0.23	23.44
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_103_geneage Exclusive	0.01	2.61	0.33	0.92	0.15
EUR_PHC_cog_last_visit_wellderly_impaired_R4_103_geneage Exclusive	Overlap	0.01	10.25	0.43	8.26	7.32
agegene_human Exclusive	Overlap	0.01	17.19	6.83	10.75	21.09
Overlap	Exclusives	0.08	3.51	35.09	5.20	53.53

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_wellderly_impaired_R4_103_geneage Exclusive	100	99	TRIM39-RPP21
agegene_human Exclusive	304	302	TERC;TOP 1.00
Overlap	3	3