Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43_geneage Exclusive	agegene_human	1.38e-02	8.45e-02	7.53e-07	3.78e-33
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_43_geneage	3.53e-01	7.32e-01	1.89e-04	1.25e-01
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43_geneage Exclusive	agegene_human Exclusive	2.56e-02	1.09e-01	2.27e-07	9.97e-33
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_43_geneage Exclusive	3.76e-01	7.04e-01	9.89e-05	2.32e-01
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43_geneage Exclusive	Overlap	2.49e-02	9.89e-01	6.56e-02	6.50e-03
agegene_human Exclusive	Overlap	9.85e-05	5.17e-01	9.85e-05	1.48e-03
Overlap	Exclusives	3.24e-01	1.12e-16	6.51e-101	4.10e-80



Evaluating how well EUR_PHC_cog_last_visit_wellderly_impaired_R4_43_geneage genes are linked to agegene_human genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43_geneage Exclusive	agegene_human	0.73	0.77	1.15	0.84	15.39
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_43_geneage	0.57	0.16	0.09	0.57	1.57
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43_geneage Exclusive	agegene_human Exclusive	0.73	0.64	0.73	0.98	16.09
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_43_geneage Exclusive	0.55	0.09	0.09	0.71	1.22
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43_geneage Exclusive	Overlap	0.95	1.71	0.36	1.36	2.41
agegene_human Exclusive	Overlap	0.99	1.84	0.92	1.11	2.26
Overlap	Exclusives	0.79	0.01	10.12	1.35	21.47

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43_geneage Exclusive	agegene_human	0.03	0.74	2.09	0.90	14.19
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_43_geneage	0.00	2.28	0.68	1.86	1.96
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43_geneage Exclusive	agegene_human Exclusive	0.03	0.63	1.65	1.10	16.61
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_43_geneage Exclusive	0.00	0.94	0.44	1.49	0.43
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43_geneage Exclusive	Overlap	0.00	2.90	-0.50	1.56	1.51
agegene_human Exclusive	Overlap	0.00	4.57	-1.04	2.84	9.41
Overlap	Exclusives	0.05	0.57	17.38	1.67	48.97

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43_geneage Exclusive	41	41	
agegene_human Exclusive	305	303	TERC;TOP 1.00
Overlap	2	2