Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_young_old_3 Exclusive	tier1_31	7.18e-01	5.71e-01	4.39e-01	7.01e-03
tier1_31 Exclusive	wellderly_young_old_3	6.52e-01	1.04e-01	8.31e-02	9.32e-02
wellderly_young_old_3 Exclusive	tier1_31 Exclusive	5.40e-01	5.40e-01	4.28e-01	1.23e-02
tier1_31 Exclusive	wellderly_young_old_3 Exclusive	8.45e-01	1.69e-01	1.62e-01	9.84e-02
wellderly_young_old_3 Exclusive	Overlap	8.91e-01	9.31e-01	9.70e-01	9.90e-01
tier1_31 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	5.94e-02
Overlap	Exclusives	7.97e-04	5.74e-04	3.24e-04	7.26e-05



Evaluating how well wellderly_young_old_3 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_young_old_3 Exclusive	tier1_31	0.64	0.41	0.70	0.55	2.57
tier1_31 Exclusive	wellderly_young_old_3	0.55	2.19	2.67	1.95	2.39
wellderly_young_old_3 Exclusive	tier1_31 Exclusive	0.64	0.76	1.02	0.70	2.91
tier1_31 Exclusive	wellderly_young_old_3 Exclusive	0.55	1.88	2.23	1.78	2.30
wellderly_young_old_3 Exclusive	Overlap	0.52	0.04	-0.22	-0.16	0.01
tier1_31 Exclusive	Overlap	0.99	2.25	1.72	1.95	1.73
Overlap	Exclusives	0.60	2.17	4.78	2.35	4.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_young_old_3 Exclusive	tier1_31	0.00	0.31	-0.00	0.16	0.83
tier1_31 Exclusive	wellderly_young_old_3	0.01	1.29	1.72	0.77	1.63
wellderly_young_old_3 Exclusive	tier1_31 Exclusive	0.00	0.50	0.14	0.35	0.11
tier1_31 Exclusive	wellderly_young_old_3 Exclusive	0.01	0.74	1.10	0.74	0.83
wellderly_young_old_3 Exclusive	Overlap	0.00	-0.24	-0.39	-0.16	-0.23
tier1_31 Exclusive	Overlap	0.01	24.68	14.55	38.92	3.57
Overlap	Exclusives	0.01	3.28	7.76	4.24	4.48

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_young_old_3 Exclusive	128	127	TRIM39-RPP21
tier1_31 Exclusive	30	29	MS4A
Overlap	1	1