Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_young_old_3_5 Exclusive	tier1_31	8.59e-01	9.20e-01	6.23e-01	7.25e-02
tier1_31 Exclusive	wellderly_young_old_3_5	8.47e-01	3.36e-01	2.80e-01	4.23e-02
wellderly_young_old_3_5 Exclusive	tier1_31 Exclusive	7.75e-01	9.37e-01	4.25e-01	7.61e-02
tier1_31 Exclusive	wellderly_young_old_3_5 Exclusive	7.58e-01	3.60e-01	3.88e-01	6.93e-02
wellderly_young_old_3_5 Exclusive	Overlap	8.12e-01	4.36e-01	7.92e-01	9.50e-01
tier1_31 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	3.92e-04	3.45e-04	2.91e-05	1.13e-06



Evaluating how well wellderly_young_old_3_5 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_young_old_3_5 Exclusive	tier1_31	0.60	-0.08	-0.25	-0.07	1.75
tier1_31 Exclusive	wellderly_young_old_3_5	0.58	1.02	1.80	1.67	2.66
wellderly_young_old_3_5 Exclusive	tier1_31 Exclusive	0.60	-0.08	-0.17	0.25	1.67
tier1_31 Exclusive	wellderly_young_old_3_5 Exclusive	0.58	1.10	2.16	1.13	2.25
wellderly_young_old_3_5 Exclusive	Overlap	0.45	-0.43	-0.72	-0.53	-0.07
tier1_31 Exclusive	Overlap	0.99	2.00	1.48	2.12	1.83
Overlap	Exclusives	0.66	1.75	4.75	2.44	5.98

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_young_old_3_5 Exclusive	tier1_31	0.00	-0.13	-0.30	-0.20	0.42
tier1_31 Exclusive	wellderly_young_old_3_5	0.00	0.31	0.74	0.83	0.71
wellderly_young_old_3_5 Exclusive	tier1_31 Exclusive	0.00	-0.03	-0.13	0.13	0.01
tier1_31 Exclusive	wellderly_young_old_3_5 Exclusive	0.00	0.00	0.45	0.02	0.83
wellderly_young_old_3_5 Exclusive	Overlap	0.00	-0.38	-0.34	-0.49	-0.20
tier1_31 Exclusive	Overlap	0.01	20.95	9.15	34.88	11.11
Overlap	Exclusives	0.01	2.60	6.59	5.10	3.78

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_young_old_3_5 Exclusive	69	68	TRIM39-RPP21
tier1_31 Exclusive	30	29	MS4A
Overlap	1	1