Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) wellderly_young_old_3_5 Exclusive tier1_31 8.59e-01 9.20e-01 6.23e-01 7.25e-02 tier1_31 Exclusive wellderly_young_old_3_5 8.47e-01 3.36e-01 2.80e-01 4.23e-02 wellderly_young_old_3_5 Exclusive tier1_31 Exclusive 7.75e-01 9.37e-01 4.25e-01 7.61e-02 tier1_31 Exclusive wellderly_young_old_3_5 Exclusive 7.58e-01 3.60e-01 3.88e-01 6.93e-02 wellderly_young_old_3_5 Exclusive Overlap 8.12e-01 4.36e-01 7.92e-01 9.50e-01 tier1_31 Exclusive Overlap 1.98e-02 1.98e-02 1.98e-02 1.98e-02 Overlap Exclusives 3.92e-04 3.45e-04 2.91e-05 1.13e-06 Evaluating how well wellderly_young_old_3_5 genes are linked to tier1_31 genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) wellderly_young_old_3_5 Exclusive tier1_31 0.60 -0.08 -0.25 -0.07 1.75 tier1_31 Exclusive wellderly_young_old_3_5 0.58 1.02 1.80 1.67 2.66 wellderly_young_old_3_5 Exclusive tier1_31 Exclusive 0.60 -0.08 -0.17 0.25 1.67 tier1_31 Exclusive wellderly_young_old_3_5 Exclusive 0.58 1.10 2.16 1.13 2.25 wellderly_young_old_3_5 Exclusive Overlap 0.45 -0.43 -0.72 -0.53 -0.07 tier1_31 Exclusive Overlap 0.99 2.00 1.48 2.12 1.83 Overlap Exclusives 0.66 1.75 4.75 2.44 5.98 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) wellderly_young_old_3_5 Exclusive tier1_31 0.00 -0.13 -0.30 -0.20 0.42 tier1_31 Exclusive wellderly_young_old_3_5 0.00 0.31 0.74 0.83 0.71 wellderly_young_old_3_5 Exclusive tier1_31 Exclusive 0.00 -0.03 -0.13 0.13 0.01 tier1_31 Exclusive wellderly_young_old_3_5 Exclusive 0.00 0.00 0.45 0.02 0.83 wellderly_young_old_3_5 Exclusive Overlap 0.00 -0.38 -0.34 -0.49 -0.20 tier1_31 Exclusive Overlap 0.01 20.95 9.15 34.88 11.11 Overlap Exclusives 0.01 2.60 6.59 5.10 3.78 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes wellderly_young_old_3_5 Exclusive 69 68 TRIM39-RPP21 tier1_31 Exclusive 30 29 MS4A Overlap 1 1