Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_young_old_3 Exclusive	agegene_human	7.13e-01	1.66e-01	1.79e-01	6.91e-36
agegene_human Exclusive	wellderly_young_old_3	3.57e-04	8.14e-01	1.17e-11	3.18e-01
wellderly_young_old_3 Exclusive	agegene_human Exclusive	8.11e-01	1.31e-01	2.95e-01	9.31e-36
agegene_human Exclusive	wellderly_young_old_3 Exclusive	2.96e-04	7.58e-01	7.96e-11	4.59e-01
wellderly_young_old_3 Exclusive	Overlap	8.71e-01	2.18e-01	2.97e-01	3.76e-01
agegene_human Exclusive	Overlap	1.98e-02	1.98e-01	1.98e-02	1.98e-02
Overlap	Exclusives	5.76e-21	1.27e-13	2.39e-102	2.65e-78



Evaluating how well wellderly_young_old_3 genes are linked to agegene_human genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_young_old_3 Exclusive	agegene_human	0.74	0.23	-0.28	0.53	15.12
agegene_human Exclusive	wellderly_young_old_3	0.52	-1.08	-0.13	0.06	0.77
wellderly_young_old_3 Exclusive	agegene_human Exclusive	0.74	0.30	-0.23	0.43	15.05
agegene_human Exclusive	wellderly_young_old_3 Exclusive	0.51	-1.08	-0.10	-0.04	0.50
wellderly_young_old_3 Exclusive	Overlap	0.80	0.08	1.12	1.07	1.04
agegene_human Exclusive	Overlap	0.99	2.37	1.51	2.31	1.93
Overlap	Exclusives	0.77	1.98	8.21	2.65	17.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_young_old_3 Exclusive	agegene_human	0.04	-0.03	0.61	0.20	23.64
agegene_human Exclusive	wellderly_young_old_3	0.01	1.46	0.25	1.18	0.31
wellderly_young_old_3 Exclusive	agegene_human Exclusive	0.04	0.01	0.60	0.30	26.31
agegene_human Exclusive	wellderly_young_old_3 Exclusive	0.01	0.78	0.05	0.41	0.08
wellderly_young_old_3 Exclusive	Overlap	0.00	-0.40	0.73	0.30	-0.09
agegene_human Exclusive	Overlap	0.01	12.67	0.03	75.34	41.57
Overlap	Exclusives	0.08	2.60	19.52	4.59	49.12

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_young_old_3 Exclusive	128	127	TRIM39-RPP21
agegene_human Exclusive	306	304	TERC;TOP 1.00
Overlap	1	1