Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_young_old_3_5 Exclusive	agegene_human	4.77e-01	2.58e-01	2.96e-07	1.32e-32
agegene_human Exclusive	wellderly_young_old_3_5	3.57e-02	7.09e-01	2.34e-08	1.90e-01
wellderly_young_old_3_5 Exclusive	agegene_human Exclusive	9.63e-01	2.09e-01	8.47e-06	6.70e-33
agegene_human Exclusive	wellderly_young_old_3_5 Exclusive	3.61e-02	8.27e-01	4.05e-08	2.88e-01
wellderly_young_old_3_5 Exclusive	Overlap	9.11e-01	2.77e-01	1.19e-01	4.36e-01
agegene_human Exclusive	Overlap	1.98e-02	2.18e-01	1.98e-02	1.98e-02
Overlap	Exclusives	1.15e-20	2.79e-15	1.04e-83	4.90e-94



Evaluating how well wellderly_young_old_3_5 genes are linked to agegene_human genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_young_old_3_5 Exclusive	agegene_human	0.73	-0.38	0.19	0.83	12.77
agegene_human Exclusive	wellderly_young_old_3_5	0.55	-0.86	-0.58	-0.24	1.44
wellderly_young_old_3_5 Exclusive	agegene_human Exclusive	0.73	0.01	0.31	0.65	14.41
agegene_human Exclusive	wellderly_young_old_3_5 Exclusive	0.54	-0.92	-0.60	-0.40	1.29
wellderly_young_old_3_5 Exclusive	Overlap	0.84	0.08	1.13	1.26	1.09
agegene_human Exclusive	Overlap	0.99	2.25	1.55	2.23	1.70
Overlap	Exclusives	0.82	1.51	9.50	2.44	20.21

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_young_old_3_5 Exclusive	agegene_human	0.04	-0.37	2.12	1.05	19.97
agegene_human Exclusive	wellderly_young_old_3_5	0.00	0.48	0.18	1.31	1.61
wellderly_young_old_3_5 Exclusive	agegene_human Exclusive	0.04	-0.14	2.53	0.88	16.80
agegene_human Exclusive	wellderly_young_old_3_5 Exclusive	0.00	-0.22	-0.32	0.55	0.35
wellderly_young_old_3_5 Exclusive	Overlap	0.00	-0.33	0.66	1.23	0.08
agegene_human Exclusive	Overlap	0.01	11.92	-0.00	94.51	24.37
Overlap	Exclusives	0.08	1.65	20.61	3.77	56.77

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_young_old_3_5 Exclusive	69	68	TRIM39-RPP21
agegene_human Exclusive	306	304	TERC;TOP 1.00
Overlap	1	1