Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_young_old_3	Kevin	4.05e-01	3.30e-01	4.51e-01	4.96e-01
Kevin	wellderly_young_old_3	9.04e-02	9.04e-01	7.48e-01	4.98e-01



Evaluating how well wellderly_young_old_3 genes are linked to Kevin genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_young_old_3	Kevin	0.54	-0.41	-0.96	-0.63	1.25
Kevin	wellderly_young_old_3	0.51	-0.20	0.11	-0.28	0.44

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_young_old_3	Kevin	0.00	-0.45	-0.38	-0.51	0.69
Kevin	wellderly_young_old_3	0.01	-0.43	-0.34	-0.33	-0.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_young_old_3	129	128	TRIM39-RPP21
Kevin	80	77	CDKN2B-AS1;KN3KRP;LINC02049