Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_young_old_3_5	Kevin	2.93e-01	2.29e-01	9.91e-01	5.77e-01
Kevin	wellderly_young_old_3_5	8.33e-02	9.41e-01	4.87e-01	2.85e-01



Evaluating how well wellderly_young_old_3_5 genes are linked to Kevin genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_young_old_3_5	Kevin	0.53	-0.61	-1.53	-0.57	0.85
Kevin	wellderly_young_old_3_5	0.54	-0.66	-0.07	-0.39	1.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_young_old_3_5	Kevin	0.00	-0.67	-1.54	-0.48	-0.16
Kevin	wellderly_young_old_3_5	0.00	-0.73	-0.41	-0.37	0.38

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_young_old_3_5	70	69	TRIM39-RPP21
Kevin	80	77	CDKN2B-AS1;LINC02049;KN3KRP