Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_old_3 Exclusive	tier1_31	1.60e-01	4.55e-01	1.22e-01	1.85e-02
tier1_31 Exclusive	wellderly_old_3	7.47e-01	6.25e-02	2.83e-02	1.43e-02
wellderly_old_3 Exclusive	tier1_31 Exclusive	1.73e-01	4.12e-01	7.25e-02	2.07e-02
tier1_31 Exclusive	wellderly_old_3 Exclusive	8.32e-01	5.07e-02	5.13e-02	1.59e-02
wellderly_old_3 Exclusive	Overlap	3.96e-01	9.70e-01	5.94e-01	7.13e-01
tier1_31 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	3.96e-02
Overlap	Exclusives	2.86e-05	1.09e-05	5.75e-06	2.32e-07



Evaluating how well wellderly_old_3 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_old_3 Exclusive	tier1_31	0.66	0.88	1.02	1.28	3.32
tier1_31 Exclusive	wellderly_old_3	0.60	2.07	2.67	2.68	2.99
wellderly_old_3 Exclusive	tier1_31 Exclusive	0.66	0.87	1.26	1.16	2.86
tier1_31 Exclusive	wellderly_old_3 Exclusive	0.60	2.08	3.23	2.67	3.03
wellderly_old_3 Exclusive	Overlap	0.64	1.04	0.12	0.55	0.45
tier1_31 Exclusive	Overlap	0.99	2.02	1.45	1.80	1.89
Overlap	Exclusives	0.66	2.22	5.28	2.46	5.84

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_old_3 Exclusive	tier1_31	0.00	0.89	0.59	0.95	3.57
tier1_31 Exclusive	wellderly_old_3	0.01	0.82	1.93	1.93	2.16
wellderly_old_3 Exclusive	tier1_31 Exclusive	0.00	0.93	0.86	0.11	0.16
tier1_31 Exclusive	wellderly_old_3 Exclusive	0.00	0.69	1.61	1.97	0.49
wellderly_old_3 Exclusive	Overlap	0.00	0.20	-0.34	-0.16	-0.24
tier1_31 Exclusive	Overlap	0.01	33.34	10.98	7.99	6.89
Overlap	Exclusives	0.01	3.83	12.64	1.17	9.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_old_3 Exclusive	71	70	TRIM39-RPP21
tier1_31 Exclusive	30	29	MS4A
Overlap	1	1