Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_old_3_5 Exclusive	TIER1_GS	6.02e-01	7.48e-01	3.82e-01	2.59e-01
TIER1_GS Exclusive	wellderly_old_3_5	8.65e-01	2.28e-01	1.58e-01	5.83e-02
wellderly_old_3_5 Exclusive	TIER1_GS Exclusive	4.39e-01	7.02e-01	3.44e-01	2.53e-01
TIER1_GS Exclusive	wellderly_old_3_5 Exclusive	8.86e-01	2.09e-01	2.26e-01	6.70e-02
wellderly_old_3_5 Exclusive	Overlap	6.93e-01	1.00e+00	9.70e-01	9.90e-01
TIER1_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	3.96e-02
Overlap	Exclusives	1.89e-05	1.42e-05	4.70e-07	3.43e-08



Evaluating how well wellderly_old_3_5 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_old_3_5 Exclusive	TIER1_GS	0.61	0.11	-0.08	0.16	2.02
TIER1_GS Exclusive	wellderly_old_3_5	0.61	1.32	1.96	2.15	2.59
wellderly_old_3_5 Exclusive	TIER1_GS Exclusive	0.61	0.32	0.09	0.12	2.06
TIER1_GS Exclusive	wellderly_old_3_5 Exclusive	0.60	0.98	1.79	1.45	2.30
wellderly_old_3_5 Exclusive	Overlap	0.54	0.10	-0.15	-0.20	0.16
TIER1_GS Exclusive	Overlap	0.99	2.18	1.63	1.91	1.83
Overlap	Exclusives	0.71	1.94	5.23	2.57	6.31

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_old_3_5 Exclusive	TIER1_GS	0.00	0.42	0.52	0.19	1.10
TIER1_GS Exclusive	wellderly_old_3_5	0.00	1.23	1.29	1.98	1.18
wellderly_old_3_5 Exclusive	TIER1_GS Exclusive	0.00	0.87	1.13	0.03	0.66
TIER1_GS Exclusive	wellderly_old_3_5 Exclusive	0.00	0.21	0.31	0.75	0.51
wellderly_old_3_5 Exclusive	Overlap	0.00	-0.25	-0.23	-0.43	-0.34
TIER1_GS Exclusive	Overlap	0.01	31.53	13.38	20.88	4.36
Overlap	Exclusives	0.01	3.38	9.26	5.59	12.44

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_old_3_5 Exclusive	40	39	TRIM39-RPP21
TIER1_GS Exclusive	30	29	MS4A
Overlap	1	1