Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_old_3_5 Exclusive	agegene_human	6.28e-01	6.70e-01	1.27e-04	2.35e-30
agegene_human Exclusive	wellderly_old_3_5	2.38e-01	4.09e-01	6.19e-08	7.85e-02
wellderly_old_3_5 Exclusive	agegene_human Exclusive	9.69e-01	7.06e-01	1.69e-04	2.01e-30
agegene_human Exclusive	wellderly_old_3_5 Exclusive	2.43e-01	3.93e-01	1.84e-07	7.46e-02
wellderly_old_3_5 Exclusive	Overlap	1.39e-01	2.18e-01	7.92e-02	2.38e-01
agegene_human Exclusive	Overlap	1.98e-02	2.38e-01	1.98e-02	1.98e-02
Overlap	Exclusives	7.68e-32	1.23e-16	2.13e-94	1.48e-99



Evaluating how well wellderly_old_3_5 genes are linked to agegene_human genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_old_3_5 Exclusive	agegene_human	0.72	0.60	0.53	0.62	13.36
agegene_human Exclusive	wellderly_old_3_5	0.57	1.05	0.38	0.94	1.54
wellderly_old_3_5 Exclusive	agegene_human Exclusive	0.72	0.32	0.44	0.58	13.71
agegene_human Exclusive	wellderly_old_3_5 Exclusive	0.56	0.97	0.24	0.73	1.40
wellderly_old_3_5 Exclusive	Overlap	0.92	1.34	1.38	1.80	1.34
agegene_human Exclusive	Overlap	0.99	1.99	1.47	2.39	1.77
Overlap	Exclusives	0.84	2.36	11.98	2.68	21.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_old_3_5 Exclusive	agegene_human	0.03	0.33	1.14	0.63	14.30
agegene_human Exclusive	wellderly_old_3_5	0.00	0.69	0.08	1.34	0.73
wellderly_old_3_5 Exclusive	agegene_human Exclusive	0.03	0.11	1.08	0.55	12.30
agegene_human Exclusive	wellderly_old_3_5 Exclusive	0.00	-0.02	0.03	0.37	0.45
wellderly_old_3_5 Exclusive	Overlap	0.00	0.58	2.60	2.05	0.66
agegene_human Exclusive	Overlap	0.01	11.67	-0.04	73.71	16.78
Overlap	Exclusives	0.09	2.78	26.01	5.00	72.59

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_old_3_5 Exclusive	40	39	TRIM39-RPP21
agegene_human Exclusive	306	304	TERC;TOP 1.00
Overlap	1	1