Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_old_3	Kevin	9.63e-02	3.88e-01	5.38e-02	7.37e-03
Kevin	wellderly_old_3	7.81e-02	1.63e-01	6.91e-02	6.25e-02



Evaluating how well wellderly_old_3 genes are linked to Kevin genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_old_3	Kevin	0.59	1.06	1.02	0.81	2.60
Kevin	wellderly_old_3	0.55	0.64	1.09	0.96	1.40

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_old_3	Kevin	0.01	0.32	0.42	0.27	0.87
Kevin	wellderly_old_3	0.00	1.09	0.55	1.07	0.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_old_3	73	71	TRIM39-RPP21;Gene_name
Kevin	80	77	CDKN2B-AS1;KN3KRP;LINC02049