Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_old_3_5	Kevin	9.38e-01	9.99e-01	2.76e-01	7.61e-02
Kevin	wellderly_old_3_5	5.59e-02	5.60e-01	2.95e-01	1.63e-01



Evaluating how well wellderly_old_3_5 genes are linked to Kevin genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_old_3_5	Kevin	0.56	0.19	-0.06	0.19	2.16
Kevin	wellderly_old_3_5	0.55	-0.29	0.10	0.31	1.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_old_3_5	Kevin	0.00	-0.16	-0.52	-0.03	0.38
Kevin	wellderly_old_3_5	0.00	0.01	0.02	0.59	0.23

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_old_3_5	41	40	TRIM39-RPP21
Kevin	80	77	LINC02049;CDKN2B-AS1;KN3KRP