Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_young_3	tier1_31	3.37e-01	1.68e-01	3.30e-01	3.92e-03
tier1_31	wellderly_young_3	6.77e-01	9.28e-01	7.69e-01	9.56e-01



Evaluating how well wellderly_young_3 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_young_3	tier1_31	0.61	0.30	0.84	0.24	2.32
tier1_31	wellderly_young_3	0.49	0.25	0.13	-0.26	-0.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_young_3	tier1_31	0.00	-0.28	-0.21	-0.38	0.02
tier1_31	wellderly_young_3	0.00	-0.25	-0.22	-0.27	-0.29

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_young_3	57	57	
tier1_31	31	30	MS4A