Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_young_3_5	tier1_31	5.21e-01	5.21e-01	1.97e-01	4.04e-02
tier1_31	wellderly_young_3_5	7.48e-01	9.47e-01	9.78e-01	6.64e-01



Evaluating how well wellderly_young_3_5 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_young_3_5	tier1_31	0.60	-0.04	0.47	-0.07	1.63
tier1_31	wellderly_young_3_5	0.54	0.27	0.43	-0.10	0.72

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_young_3_5	tier1_31	0.00	-0.52	-0.48	-0.45	-0.01
tier1_31	wellderly_young_3_5	0.00	-0.50	-0.41	-0.61	-0.16

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_young_3_5	29	29	
tier1_31	31	30	MS4A