Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_young_3_5	agegene_human	3.93e-01	1.17e-01	3.14e-05	6.14e-27
agegene_human	wellderly_young_3_5	5.39e-02	3.14e-01	1.60e-02	5.52e-01



Evaluating how well wellderly_young_3_5 genes are linked to agegene_human genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_young_3_5	agegene_human	0.71	-0.84	-0.40	0.15	13.52
agegene_human	wellderly_young_3_5	0.52	-2.81	-1.33	-1.46	0.49

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_young_3_5	agegene_human	0.03	-0.67	1.75	0.32	14.48
agegene_human	wellderly_young_3_5	0.00	-0.09	-0.70	0.41	1.25

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_young_3_5	29	29	
agegene_human	307	305	TERC;TOP 1.00