Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_young_3	Kevin	1.73e-02	2.47e-03	1.45e-02	1.97e-01
Kevin	wellderly_young_3	1.08e-01	8.04e-01	6.57e-01	7.00e-01



Evaluating how well wellderly_young_3 genes are linked to Kevin genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_young_3	Kevin	0.48	-1.40	-2.97	-1.56	-0.44
Kevin	wellderly_young_3	0.47	-0.95	-0.89	-1.02	-1.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_young_3	Kevin	0.00	-0.97	-0.64	-1.01	-0.51
Kevin	wellderly_young_3	0.00	-1.47	-1.01	-1.12	-0.77

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_young_3	57	57	
Kevin	80	77	CDKN2B-AS1;KN3KRP;LINC02049