Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R2_54	tier1_31	2.62e-03	2.28e-04	2.68e-04	2.67e-06
tier1_31	EUR_PHC_cog_last_visit_wellderly_R2_54	6.79e-01	2.71e-01	1.74e-01	2.16e-01



Evaluating how well EUR_PHC_cog_last_visit_wellderly_R2_54 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R2_54	tier1_31	0.77	2.11	4.14	3.32	5.21
tier1_31	EUR_PHC_cog_last_visit_wellderly_R2_54	0.55	0.78	1.44	1.24	1.47

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R2_54	tier1_31	0.00	3.79	5.15	3.86	6.14
tier1_31	EUR_PHC_cog_last_visit_wellderly_R2_54	0.00	3.39	2.77	3.11	3.68

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_wellderly_R2_54	54	52	RFPL2;TRIM39-RPP21
tier1_31	31	30	MS4A