Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	tier1_31	7.21e-01	6.66e-01	8.17e-01	5.06e-01
tier1_31 Exclusive	EUR_PHC_cog_last_visit_impaired_R2_58	4.11e-01	7.38e-01	8.68e-01	3.44e-01
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	tier1_31 Exclusive	9.23e-01	8.09e-01	9.87e-01	3.21e-01
tier1_31 Exclusive	EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	3.59e-01	9.01e-01	8.63e-01	5.18e-01
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	Overlap	5.92e-01	5.55e-01	5.92e-01	5.17e-01
tier1_31 Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	1.28e-06	1.24e-05	9.34e-14	5.11e-06



Evaluating how well EUR_PHC_cog_last_visit_impaired_R2_58 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	tier1_31	0.56	-0.58	-0.77	-0.39	1.46
tier1_31 Exclusive	EUR_PHC_cog_last_visit_impaired_R2_58	0.55	0.04	0.11	0.01	1.19
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	tier1_31 Exclusive	0.56	-0.36	-0.79	-0.44	1.33
tier1_31 Exclusive	EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	0.53	-0.38	-0.23	-0.37	0.69
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	Overlap	0.62	-1.00	-0.84	-0.44	0.40
tier1_31 Exclusive	Overlap	1.00	2.14	1.98	2.42	2.74
Overlap	Exclusives	0.67	5.16	5.07	3.03	5.54

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	tier1_31	0.00	-0.47	-0.60	-0.24	0.47
tier1_31 Exclusive	EUR_PHC_cog_last_visit_impaired_R2_58	0.01	3.88	4.61	3.38	2.05
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	tier1_31 Exclusive	0.00	-0.49	-0.57	-0.39	0.17
tier1_31 Exclusive	EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	0.00	-0.60	-0.42	-0.49	-0.06
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	Overlap	0.00	0.42	1.66	1.25	4.21
tier1_31 Exclusive	Overlap	0.05	96.68	89.55	92.92	134.88
Overlap	Exclusives	0.05	75.84	78.23	48.39	73.50

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	56	56	
tier1_31 Exclusive	29	28	MS4A
Overlap	2	2