Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	agegene_human	2.26e-09	8.15e-07	1.67e-12	1.49e-55
agegene_human Exclusive	EUR_PHC_cog_last_visit_impaired_R2_58	1.37e-01	8.52e-02	1.46e-09	8.97e-03
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	agegene_human Exclusive	3.06e-09	1.04e-06	5.86e-11	7.69e-56
agegene_human Exclusive	EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	1.59e-01	1.38e-01	2.01e-08	6.00e-02
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	Overlap	4.15e-01	2.06e-01	3.77e-01	1.41e-01
agegene_human Exclusive	Overlap	2.06e-01	3.41e-01	8.41e-03	8.41e-03
Overlap	Exclusives	3.96e-08	8.63e-10	2.19e-95	6.04e-61



Evaluating how well EUR_PHC_cog_last_visit_impaired_R2_58 genes are linked to agegene_human genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	agegene_human	0.78	2.89	6.57	2.09	16.88
agegene_human Exclusive	EUR_PHC_cog_last_visit_impaired_R2_58	0.61	3.53	2.26	2.45	2.54
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	agegene_human Exclusive	0.78	2.96	7.26	2.67	17.79
agegene_human Exclusive	EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	0.58	3.56	2.12	2.36	1.85
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	Overlap	0.80	0.50	0.67	0.46	1.92
agegene_human Exclusive	Overlap	0.91	0.50	2.04	1.02	2.89
Overlap	Exclusives	0.77	2.14	7.58	1.18	17.95

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	agegene_human	0.04	3.50	10.89	1.91	26.85
agegene_human Exclusive	EUR_PHC_cog_last_visit_impaired_R2_58	0.01	3.14	4.90	3.32	2.93
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	agegene_human Exclusive	0.04	3.57	12.15	3.51	31.59
agegene_human Exclusive	EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	0.00	7.17	4.13	2.97	1.31
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	Overlap	0.00	2.70	5.13	2.67	1.90
agegene_human Exclusive	Overlap	0.00	-1.11	1.19	0.75	0.36
Overlap	Exclusives	0.05	3.69	13.50	1.92	30.39

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	54	54	
agegene_human Exclusive	303	301	TOP 1.00;TERC
Overlap	4	4