Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R2_54	Kevin	9.04e-01	9.88e-01	9.92e-01	3.07e-01
Kevin	EUR_PHC_cog_last_visit_wellderly_R2_54	1.73e-01	8.41e-01	4.51e-01	7.70e-01



Evaluating how well EUR_PHC_cog_last_visit_wellderly_R2_54 genes are linked to Kevin genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R2_54	Kevin	0.55	-0.33	-0.35	-0.08	1.67
Kevin	EUR_PHC_cog_last_visit_wellderly_R2_54	0.51	-0.05	-0.35	0.21	0.20

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R2_54	Kevin	0.00	-0.49	-0.64	-0.28	0.52
Kevin	EUR_PHC_cog_last_visit_wellderly_R2_54	0.00	0.06	-0.42	0.06	-0.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_wellderly_R2_54	54	52	RFPL2;TRIM39-RPP21
Kevin	80	77	KN3KRP;LINC02049;CDKN2B-AS1