Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	Kevin	2.24e-04	1.97e-04	1.98e-05	4.97e-06
Kevin Exclusive	EUR_PHC_cog_last_visit_impaired_R2_58	1.79e-01	2.33e-01	9.40e-02	1.86e-01
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	Kevin Exclusive	3.30e-04	2.08e-04	1.09e-05	8.48e-06
Kevin Exclusive	EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	1.61e-01	3.37e-01	1.72e-01	2.14e-01
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	Overlap	5.94e-02	1.98e-02	3.96e-02	3.96e-02
Kevin Exclusive	Overlap	2.57e-01	1.98e-02	7.92e-02	1.19e-01
Overlap	Exclusives	1.50e-01	7.63e-01	1.31e-30	2.60e-01



Evaluating how well EUR_PHC_cog_last_visit_impaired_R2_58 genes are linked to Kevin genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	Kevin	0.65	2.51	3.87	2.37	4.78
Kevin Exclusive	EUR_PHC_cog_last_visit_impaired_R2_58	0.57	0.68	0.84	1.23	1.99
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	Kevin Exclusive	0.65	2.32	3.33	2.43	4.35
Kevin Exclusive	EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	0.57	1.03	0.81	1.07	1.78
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	Overlap	0.99	1.27	134349838515701.00	1.31	1.76
Kevin Exclusive	Overlap	0.97	0.63	881225442216575.00	0.97	1.59
Overlap	Exclusives	0.55	-150686992498970.00	-0.78	-0.08	1.96

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	Kevin	0.01	6.78	13.64	6.70	3.61
Kevin Exclusive	EUR_PHC_cog_last_visit_impaired_R2_58	0.01	8.46	9.82	8.85	7.08
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	Kevin Exclusive	0.01	6.22	9.94	6.38	10.31
Kevin Exclusive	EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	0.01	10.07	8.40	1.95	2.07
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	Overlap	0.00	4.52	inf	6.56	1.27
Kevin Exclusive	Overlap	0.00	-0.12	20740945745735456.00	0.64	1.79
Overlap	Exclusives	0.02	5797912205891140.00	11.88	5.17	19.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_impaired_R2_58 Exclusive	57	57	
Kevin Exclusive	79	76	LINC02049;CDKN2B-AS1;KN3KRP
Overlap	1	1