Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R2_112 Exclusive	Kevin	1.01e-03	1.88e-03	1.37e-04	1.23e-05
Kevin Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_112	6.35e-02	4.56e-01	2.60e-01	2.48e-01
EUR_PHC_cog_last_visit_wellderly_impaired_R2_112 Exclusive	Kevin Exclusive	8.01e-04	2.50e-03	7.00e-05	2.39e-05
Kevin Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_112 Exclusive	1.04e-01	4.64e-01	2.49e-01	3.23e-01
EUR_PHC_cog_last_visit_wellderly_impaired_R2_112 Exclusive	Overlap	7.92e-02	1.98e-02	7.92e-02	3.96e-02
Kevin Exclusive	Overlap	1.58e-01	1.98e-02	3.96e-02	1.39e-01
Overlap	Exclusives	2.33e-01	7.22e-01	3.34e-41	1.71e-01



Evaluating how well EUR_PHC_cog_last_visit_wellderly_impaired_R2_112 genes are linked to Kevin genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R2_112 Exclusive	Kevin	0.64	1.66	3.38	1.62	4.36
Kevin Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_112	0.54	0.66	0.44	0.80	1.67
EUR_PHC_cog_last_visit_wellderly_impaired_R2_112 Exclusive	Kevin Exclusive	0.63	2.02	2.91	2.07	4.53
Kevin Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_112 Exclusive	0.54	0.77	0.43	0.78	1.44
EUR_PHC_cog_last_visit_wellderly_impaired_R2_112 Exclusive	Overlap	0.99	1.23	6743457901023.60	1.05	1.69
Kevin Exclusive	Overlap	0.97	0.62	881225442216575.00	1.09	1.71
Overlap	Exclusives	0.54	-inf	-0.37	0.12	2.07

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R2_112 Exclusive	Kevin	0.01	2.43	5.89	3.15	2.89
Kevin Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_112	0.01	5.18	3.64	4.97	3.93
EUR_PHC_cog_last_visit_wellderly_impaired_R2_112 Exclusive	Kevin Exclusive	0.01	2.59	5.86	3.41	6.54
Kevin Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_112 Exclusive	0.01	4.90	4.18	4.18	3.50
EUR_PHC_cog_last_visit_wellderly_impaired_R2_112 Exclusive	Overlap	0.00	1.68	4270079646692026.00	5.01	2.09
Kevin Exclusive	Overlap	0.00	-0.03	20740945745735456.00	0.86	0.41
Overlap	Exclusives	0.02	1991875783350066.00	8.85	5.32	11.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_wellderly_impaired_R2_112 Exclusive	111	109	RFPL2;TRIM39-RPP21
Kevin Exclusive	79	76	CDKN2B-AS1;LINC02049;KN3KRP
Overlap	1	1