Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R2_196 Exclusive	Kevin	1.94e-01	2.67e-01	4.67e-02	3.85e-04
Kevin Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_196	1.34e-03	1.71e-01	1.37e-01	8.72e-02
EUR_PHC_cog_last_visit_wellderly_impaired_R2_196 Exclusive	Kevin Exclusive	2.00e-01	1.81e-01	5.39e-02	1.42e-03
Kevin Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_196 Exclusive	2.17e-03	1.95e-01	1.61e-01	1.15e-01
EUR_PHC_cog_last_visit_wellderly_impaired_R2_196 Exclusive	Overlap	1.39e-01	1.98e-02	9.90e-02	1.98e-02
Kevin Exclusive	Overlap	1.98e-01	1.98e-02	9.90e-02	1.19e-01
Overlap	Exclusives	7.41e-02	3.31e-01	4.25e-77	1.13e-03



Evaluating how well EUR_PHC_cog_last_visit_wellderly_impaired_R2_196 genes are linked to Kevin genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R2_196 Exclusive	Kevin	0.62	1.41	1.57	1.44	3.50
Kevin Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_196	0.53	0.31	-0.09	0.51	1.78
EUR_PHC_cog_last_visit_wellderly_impaired_R2_196 Exclusive	Kevin Exclusive	0.61	1.33	1.87	1.22	3.21
Kevin Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_196 Exclusive	0.53	0.30	0.07	0.44	1.39
EUR_PHC_cog_last_visit_wellderly_impaired_R2_196 Exclusive	Overlap	0.99	0.77	14737628023424.33	0.94	1.71
Kevin Exclusive	Overlap	0.97	0.59	881225442216575.00	1.05	1.59
Overlap	Exclusives	0.56	-171826313530992.00	1.48	1.39	3.42

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R2_196 Exclusive	Kevin	0.01	1.38	1.71	1.48	1.13
Kevin Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_196	0.01	2.84	2.12	2.71	2.89
EUR_PHC_cog_last_visit_wellderly_impaired_R2_196 Exclusive	Kevin Exclusive	0.01	0.47	1.92	0.77	2.79
Kevin Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R2_196 Exclusive	0.01	2.66	1.79	2.26	2.18
EUR_PHC_cog_last_visit_wellderly_impaired_R2_196 Exclusive	Overlap	0.00	0.45	inf	1.83	8.90
Kevin Exclusive	Overlap	0.00	-0.14	20740945745735456.00	0.59	1.77
Overlap	Exclusives	0.02	inf	6.87	4.05	8.64

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_wellderly_impaired_R2_196 Exclusive	195	193	TRIM39-RPP21;RFPL2
Kevin Exclusive	79	76	CDKN2B-AS1;KN3KRP;LINC02049
Overlap	1	1