Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R2_95	tier1_31	3.92e-03	1.56e-03	1.58e-03	2.27e-05
tier1_31	EUR_PHC_cog_last_visit_wellderly_R2_95	1.52e-01	1.38e-01	1.51e-01	2.58e-01



Evaluating how well EUR_PHC_cog_last_visit_wellderly_R2_95 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R2_95	tier1_31	0.76	1.64	3.73	2.18	4.57
tier1_31	EUR_PHC_cog_last_visit_wellderly_R2_95	0.54	1.07	1.60	1.52	1.11

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R2_95	tier1_31	0.00	1.01	2.72	2.34	5.92
tier1_31	EUR_PHC_cog_last_visit_wellderly_R2_95	0.01	2.21	1.13	2.46	1.60

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_wellderly_R2_95	95	93	TRIM39-RPP21;RFPL2
tier1_31	31	30	MS4A