Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	tier1_31	3.46e-01	2.50e-01	7.18e-02	4.59e-03
tier1_31 Exclusive	EUR_PHC_cog_last_visit_Impaired_R2_101	1.44e-01	8.92e-02	6.08e-02	1.46e-02
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	tier1_31 Exclusive	2.96e-01	1.67e-01	8.96e-02	9.49e-03
tier1_31 Exclusive	EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	3.61e-01	2.06e-01	1.27e-01	1.71e-02
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	Overlap	4.58e-01	7.76e-01	8.25e-01	8.01e-01
tier1_31 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-06
Overlap	Exclusives	4.09e-04	4.88e-04	2.97e-20	6.86e-07



Evaluating how well EUR_PHC_cog_last_visit_Impaired_R2_101 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	tier1_31	0.64	0.85	1.66	0.86	2.61
tier1_31 Exclusive	EUR_PHC_cog_last_visit_Impaired_R2_101	0.59	1.77	2.30	2.09	3.03
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	tier1_31 Exclusive	0.64	0.77	1.59	0.74	2.44
tier1_31 Exclusive	EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	0.58	1.59	1.70	1.41	2.77
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	Overlap	0.63	-1.24	-0.73	-0.68	0.92
tier1_31 Exclusive	Overlap	1.00	2.96	2.69	2.62	3.17
Overlap	Exclusives	0.66	3.64	5.20	2.79	6.61

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	tier1_31	0.00	2.27	1.52	1.38	4.58
tier1_31 Exclusive	EUR_PHC_cog_last_visit_Impaired_R2_101	0.01	6.98	6.77	6.60	2.73
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	tier1_31 Exclusive	0.00	1.16	0.98	0.88	2.13
tier1_31 Exclusive	EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	0.01	1.27	1.79	1.67	2.23
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	Overlap	0.00	0.25	2.98	0.43	2.38
tier1_31 Exclusive	Overlap	0.06	131.21	153.11	256.90	41.99
Overlap	Exclusives	0.06	57.12	92.36	17.03	36.16

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	98	98	
tier1_31 Exclusive	28	27	MS4A
Overlap	3	3