Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R2_95 Exclusive	agegene_human	5.55e-02	1.46e-02	1.19e-01	1.15e-33
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_R2_95	3.44e-03	7.57e-01	2.56e-05	6.36e-01
EUR_PHC_cog_last_visit_wellderly_R2_95 Exclusive	agegene_human Exclusive	5.22e-02	1.83e-02	3.48e-01	2.17e-32
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_R2_95 Exclusive	1.01e-03	7.13e-01	5.19e-05	5.77e-01
EUR_PHC_cog_last_visit_wellderly_R2_95 Exclusive	Overlap	6.53e-01	8.51e-01	5.54e-01	5.54e-01
agegene_human Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.39e-01
Overlap	Exclusives	4.94e-10	1.43e-11	4.69e-14	8.63e-56



Evaluating how well EUR_PHC_cog_last_visit_wellderly_R2_95 genes are linked to agegene_human genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R2_95 Exclusive	agegene_human	0.71	-0.40	-2.22	-0.08	14.82
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_R2_95	0.51	-0.86	0.07	0.86	0.22
EUR_PHC_cog_last_visit_wellderly_R2_95 Exclusive	agegene_human Exclusive	0.71	-0.34	-1.66	-0.02	12.26
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_R2_95 Exclusive	0.50	-1.53	-0.21	0.53	0.19
EUR_PHC_cog_last_visit_wellderly_R2_95 Exclusive	Overlap	0.70	0.57	0.56	0.74	0.82
agegene_human Exclusive	Overlap	0.94	5.50	1.50	2.08	1.60
Overlap	Exclusives	0.75	1.21	8.77	1.54	16.58

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R2_95 Exclusive	agegene_human	0.03	-0.68	-2.96	-0.45	17.47
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_R2_95	0.00	0.78	-0.28	1.02	-0.21
EUR_PHC_cog_last_visit_wellderly_R2_95 Exclusive	agegene_human Exclusive	0.03	-0.60	-2.41	-0.32	12.98
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_R2_95 Exclusive	0.00	0.04	-0.42	0.55	-0.17
EUR_PHC_cog_last_visit_wellderly_R2_95 Exclusive	Overlap	0.00	-0.17	-0.04	-0.13	-0.11
agegene_human Exclusive	Overlap	0.00	46.17	3.65	5.44	0.51
Overlap	Exclusives	0.06	1.45	18.94	2.36	37.81

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_wellderly_R2_95 Exclusive	94	92	RFPL2;TRIM39-RPP21
agegene_human Exclusive	306	304	TERC;TOP 1.00
Overlap	1	1