Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	agegene_human	8.55e-04	1.97e-04	3.17e-10	7.78e-53
agegene_human Exclusive	EUR_PHC_cog_last_visit_Impaired_R2_101	1.18e-01	2.35e-01	4.04e-13	2.21e-03
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	agegene_human Exclusive	3.65e-03	7.52e-05	2.50e-10	2.97e-49
agegene_human Exclusive	EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	8.46e-02	3.14e-01	1.47e-11	8.53e-03
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	Overlap	3.87e-01	1.06e-01	1.01e-01	3.61e-03
agegene_human Exclusive	Overlap	3.17e-02	2.04e-01	7.20e-04	1.50e-03
Overlap	Exclusives	1.26e-23	1.47e-19	2.40e-92	7.24e-67



Evaluating how well EUR_PHC_cog_last_visit_Impaired_R2_101 genes are linked to agegene_human genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	agegene_human	0.79	1.99	6.78	2.19	16.82
agegene_human Exclusive	EUR_PHC_cog_last_visit_Impaired_R2_101	0.61	5.44	2.49	2.88	3.98
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	agegene_human Exclusive	0.78	1.92	5.60	2.37	17.49
agegene_human Exclusive	EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	0.59	5.51	2.21	2.64	3.38
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	Overlap	0.86	0.81	1.17	1.20	2.91
agegene_human Exclusive	Overlap	0.93	0.65	2.26	1.57	3.14
Overlap	Exclusives	0.79	3.24	10.51	2.23	18.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	agegene_human	0.05	1.75	12.14	2.74	40.91
agegene_human Exclusive	EUR_PHC_cog_last_visit_Impaired_R2_101	0.02	40.16	20.09	21.78	19.37
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	agegene_human Exclusive	0.05	1.73	10.34	3.21	36.85
agegene_human Exclusive	EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	0.01	6.58	2.13	2.38	2.77
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	Overlap	0.00	0.99	2.14	4.20	5.66
agegene_human Exclusive	Overlap	0.21	73.36	105.00	218.04	441.03
Overlap	Exclusives	0.09	6.94	28.00	7.19	67.08

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	96	96	
agegene_human Exclusive	302	300	TOP 1.00;TERC
Overlap	5	5