Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R2_95	Kevin	6.96e-01	6.69e-01	4.46e-01	1.17e-01
Kevin	EUR_PHC_cog_last_visit_wellderly_R2_95	1.48e-02	2.88e-01	4.21e-01	4.21e-01



Evaluating how well EUR_PHC_cog_last_visit_wellderly_R2_95 genes are linked to Kevin genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R2_95	Kevin	0.54	-0.25	-0.50	-0.34	1.34
Kevin	EUR_PHC_cog_last_visit_wellderly_R2_95	0.48	-0.52	-0.92	-0.44	-0.58

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R2_95	Kevin	0.00	-0.75	-1.33	-0.55	-0.01
Kevin	EUR_PHC_cog_last_visit_wellderly_R2_95	0.00	-0.11	-0.63	-0.26	-0.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_wellderly_R2_95	95	93	RFPL2;TRIM39-RPP21
Kevin	80	77	LINC02049;CDKN2B-AS1;KN3KRP