Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	Kevin	1.48e-03	2.55e-03	1.11e-05	2.09e-06
Kevin Exclusive	EUR_PHC_cog_last_visit_Impaired_R2_101	4.60e-02	5.81e-01	1.44e-01	2.36e-02
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	Kevin Exclusive	1.23e-03	4.99e-03	4.06e-05	1.36e-05
Kevin Exclusive	EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	4.85e-02	6.00e-01	1.68e-01	6.43e-02
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	Overlap	7.92e-02	1.98e-02	3.96e-02	1.98e-02
Kevin Exclusive	Overlap	1.58e-01	1.98e-02	5.94e-02	7.92e-02
Overlap	Exclusives	1.06e-01	9.06e-01	5.42e-46	9.64e-03



Evaluating how well EUR_PHC_cog_last_visit_Impaired_R2_101 genes are linked to Kevin genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	Kevin	0.65	2.67	3.70	2.26	5.01
Kevin Exclusive	EUR_PHC_cog_last_visit_Impaired_R2_101	0.57	0.70	0.84	0.99	2.86
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	Kevin Exclusive	0.65	2.43	3.69	1.91	4.69
Kevin Exclusive	EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	0.57	0.80	0.72	1.30	2.22
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	Overlap	1.00	0.97	735816516575007.00	1.12	1.59
Kevin Exclusive	Overlap	0.97	0.62	881225442216575.00	0.90	1.60
Overlap	Exclusives	0.57	-80628161771715.00	0.58	0.71	3.00

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	Kevin	0.01	3.05	6.04	1.52	7.09
Kevin Exclusive	EUR_PHC_cog_last_visit_Impaired_R2_101	0.01	5.18	4.61	4.51	3.06
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	Kevin Exclusive	0.01	2.98	5.34	2.53	2.18
Kevin Exclusive	EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	0.01	4.09	5.12	5.71	1.92
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	Overlap	0.01	2.26	inf	3.65	11.82
Kevin Exclusive	Overlap	0.00	-0.08	20740945745735456.00	0.60	2.90
Overlap	Exclusives	0.02	4733511790561099.00	9.50	5.99	12.76

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_Impaired_R2_101 Exclusive	100	100	
Kevin Exclusive	79	76	CDKN2B-AS1;KN3KRP;LINC02049
Overlap	1	1