Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	Kevin	2.31e-01	9.85e-01	1.85e-01	6.89e-02
Kevin Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_43	2.97e-01	8.47e-01	9.16e-01	5.46e-01
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	Kevin Exclusive	5.30e-01	9.76e-01	1.09e-01	6.63e-02
Kevin Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	2.87e-01	8.70e-01	9.04e-01	4.89e-01
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	Overlap	1.19e-01	1.98e-02	1.19e-01	3.96e-02
Kevin Exclusive	Overlap	2.38e-01	1.98e-02	7.92e-02	5.94e-02
Overlap	Exclusives	3.50e-01	8.06e-01	2.05e-31	6.70e-02



Evaluating how well EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 genes are linked to Kevin genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	Kevin	0.56	0.68	-0.30	0.23	1.93
Kevin Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_43	0.54	-0.39	-0.03	-0.11	0.86
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	Kevin Exclusive	0.56	0.33	-0.15	0.40	1.91
Kevin Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	0.53	-0.30	-0.08	-0.23	0.83
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	Overlap	0.98	1.38	39355843590997.34	1.21	1.82
Kevin Exclusive	Overlap	0.97	0.68	881225442216575.00	0.96	1.70
Overlap	Exclusives	0.56	-inf	0.02	-0.03	2.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	Kevin	0.00	0.31	-0.34	-0.02	1.06
Kevin Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_43	0.00	-0.65	-0.12	-0.08	0.09
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	Kevin Exclusive	0.00	-0.05	-0.33	-0.00	0.17
Kevin Exclusive	EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	0.00	-0.54	-0.29	-0.30	-0.12
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	Overlap	0.00	2.34	inf	1.84	3.34
Kevin Exclusive	Overlap	0.00	-0.12	20740945745735456.00	0.62	0.57
Overlap	Exclusives	0.01	553886837524813.31	2.32	0.51	2.32

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_wellderly_impaired_R4_43 Exclusive	42	42	
Kevin Exclusive	79	76	LINC02049;KN3KRP;CDKN2B-AS1
Overlap	1	1