Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R4_55 Exclusive	agegene_human	2.08e-01	8.24e-01	3.79e-02	2.02e-29
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_R4_55	1.88e-01	5.45e-01	1.13e-06	1.35e-01
EUR_PHC_cog_last_visit_wellderly_R4_55 Exclusive	agegene_human Exclusive	1.05e-01	8.32e-01	9.76e-03	9.66e-30
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_R4_55 Exclusive	1.59e-01	6.30e-01	3.87e-06	1.72e-01
EUR_PHC_cog_last_visit_wellderly_R4_55 Exclusive	Overlap	5.35e-01	6.73e-01	2.97e-01	2.57e-01
agegene_human Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.78e-08	2.77e-07	7.95e-41	3.91e-56



Evaluating how well EUR_PHC_cog_last_visit_wellderly_R4_55 genes are linked to agegene_human genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R4_55 Exclusive	agegene_human	0.71	-0.37	-0.46	0.34	13.93
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_R4_55	0.57	-0.30	0.85	1.35	1.68
EUR_PHC_cog_last_visit_wellderly_R4_55 Exclusive	agegene_human Exclusive	0.71	-0.57	-0.55	0.52	12.94
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_R4_55 Exclusive	0.56	-0.22	0.70	0.89	1.55
EUR_PHC_cog_last_visit_wellderly_R4_55 Exclusive	Overlap	0.84	0.79	0.63	1.14	1.40
agegene_human Exclusive	Overlap	1.00	2.67	1.42	2.03	1.79
Overlap	Exclusives	0.77	0.61	4.19	1.28	18.98

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R4_55 Exclusive	agegene_human	0.03	-0.32	0.01	0.35	18.47
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_R4_55	0.00	1.59	0.35	1.80	1.17
EUR_PHC_cog_last_visit_wellderly_R4_55 Exclusive	agegene_human Exclusive	0.03	-0.57	0.01	0.70	15.31
agegene_human Exclusive	EUR_PHC_cog_last_visit_wellderly_R4_55 Exclusive	0.00	0.34	-0.35	0.79	0.83
EUR_PHC_cog_last_visit_wellderly_R4_55 Exclusive	Overlap	0.00	-0.06	-0.28	0.54	0.28
agegene_human Exclusive	Overlap	0.01	48.55	22.81	41.15	18.63
Overlap	Exclusives	0.07	1.90	15.48	2.72	56.40

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_wellderly_R4_55 Exclusive	54	53	TRIM39-RPP21
agegene_human Exclusive	306	304	TERC;TOP 1.00
Overlap	1	1