Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R4_55	Kevin	6.61e-02	1.36e-01	7.97e-02	5.75e-03
Kevin	EUR_PHC_cog_last_visit_wellderly_R4_55	7.59e-03	2.98e-01	4.55e-01	4.63e-01



Evaluating how well EUR_PHC_cog_last_visit_wellderly_R4_55 genes are linked to Kevin genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R4_55	Kevin	0.55	-0.39	-0.56	0.10	1.71
Kevin	EUR_PHC_cog_last_visit_wellderly_R4_55	0.49	-1.65	-1.21	-1.09	-0.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R4_55	Kevin	0.00	-0.49	-1.18	-0.41	0.05
Kevin	EUR_PHC_cog_last_visit_wellderly_R4_55	0.00	-1.17	-0.35	-0.70	-0.23

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_wellderly_R4_55	55	54	TRIM39-RPP21
Kevin	80	77	CDKN2B-AS1;LINC02049;KN3KRP