Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_Impaired_R4_48 Exclusive	agegene_human	2.01e-02	1.14e-01	8.20e-01	1.27e-30
agegene_human Exclusive	EUR_PHC_cog_last_visit_Impaired_R4_48	3.63e-01	8.77e-01	1.65e-03	9.29e-01
EUR_PHC_cog_last_visit_Impaired_R4_48 Exclusive	agegene_human Exclusive	3.55e-02	1.18e-01	8.24e-01	2.52e-30
agegene_human Exclusive	EUR_PHC_cog_last_visit_Impaired_R4_48 Exclusive	3.53e-01	8.68e-01	1.77e-03	9.78e-01
EUR_PHC_cog_last_visit_Impaired_R4_48 Exclusive	Overlap	1.03e-02	5.17e-01	4.89e-02	1.34e-02
agegene_human Exclusive	Overlap	9.85e-05	5.17e-01	9.85e-05	1.48e-03
Overlap	Exclusives	1.71e-01	8.57e-18	5.66e-111	1.14e-76



Evaluating how well EUR_PHC_cog_last_visit_Impaired_R4_48 genes are linked to agegene_human genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_Impaired_R4_48 Exclusive	agegene_human	0.71	0.78	2.26	0.16	12.19
agegene_human Exclusive	EUR_PHC_cog_last_visit_Impaired_R4_48	0.52	2.08	0.32	0.31	0.44
EUR_PHC_cog_last_visit_Impaired_R4_48 Exclusive	agegene_human Exclusive	0.70	0.85	2.21	0.17	12.38
agegene_human Exclusive	EUR_PHC_cog_last_visit_Impaired_R4_48 Exclusive	0.50	1.85	0.38	0.41	0.07
EUR_PHC_cog_last_visit_Impaired_R4_48 Exclusive	Overlap	0.96	1.94	1.43	1.52	2.13
agegene_human Exclusive	Overlap	0.99	1.72	0.99	1.17	2.34
Overlap	Exclusives	0.79	-0.19	10.93	1.62	19.74

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_Impaired_R4_48 Exclusive	agegene_human	0.03	0.62	3.12	-0.15	10.99
agegene_human Exclusive	EUR_PHC_cog_last_visit_Impaired_R4_48	0.00	4.72	0.71	1.01	0.67
EUR_PHC_cog_last_visit_Impaired_R4_48 Exclusive	agegene_human Exclusive	0.03	0.69	2.93	-0.13	9.10
agegene_human Exclusive	EUR_PHC_cog_last_visit_Impaired_R4_48 Exclusive	0.00	3.53	0.81	0.40	-0.20
EUR_PHC_cog_last_visit_Impaired_R4_48 Exclusive	Overlap	0.00	6.66	5.93	2.61	0.57
agegene_human Exclusive	Overlap	0.00	4.13	-0.98	2.69	6.96
Overlap	Exclusives	0.06	0.52	18.50	2.11	36.27

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_Impaired_R4_48 Exclusive	46	46	
agegene_human Exclusive	305	303	TOP 1.00;TERC
Overlap	2	2