Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R4_21 Exclusive	tier1_31	7.75e-01	6.79e-01	7.75e-01	6.15e-02
tier1_31 Exclusive	EUR_PHC_cog_last_visit_wellderly_R4_21	2.25e-01	8.40e-01	9.21e-01	8.31e-01
EUR_PHC_cog_last_visit_wellderly_R4_21 Exclusive	tier1_31 Exclusive	6.77e-01	7.69e-01	9.06e-01	5.07e-02
tier1_31 Exclusive	EUR_PHC_cog_last_visit_wellderly_R4_21 Exclusive	1.90e-01	8.47e-01	8.66e-01	8.01e-01
EUR_PHC_cog_last_visit_wellderly_R4_21 Exclusive	Overlap	5.15e-01	3.17e-01	7.33e-01	7.13e-01
tier1_31 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	3.96e-02
Overlap	Exclusives	3.12e-07	9.72e-07	4.62e-08	6.84e-08



Evaluating how well EUR_PHC_cog_last_visit_wellderly_R4_21 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R4_21 Exclusive	tier1_31	0.59	-0.21	-0.39	-0.48	1.58
tier1_31 Exclusive	EUR_PHC_cog_last_visit_wellderly_R4_21	0.54	-0.08	-0.11	-0.01	0.62
EUR_PHC_cog_last_visit_wellderly_R4_21 Exclusive	tier1_31 Exclusive	0.59	-0.31	-0.16	-0.30	1.64
tier1_31 Exclusive	EUR_PHC_cog_last_visit_wellderly_R4_21 Exclusive	0.52	-0.49	-0.31	-0.52	0.36
EUR_PHC_cog_last_visit_wellderly_R4_21 Exclusive	Overlap	0.40	-0.90	-0.94	-0.65	-0.46
tier1_31 Exclusive	Overlap	0.99	1.99	1.49	2.00	1.69
Overlap	Exclusives	0.74	2.05	5.50	2.93	5.75

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R4_21 Exclusive	tier1_31	0.00	-0.50	-0.42	-0.44	0.06
tier1_31 Exclusive	EUR_PHC_cog_last_visit_wellderly_R4_21	0.00	0.71	0.45	0.91	0.72
EUR_PHC_cog_last_visit_wellderly_R4_21 Exclusive	tier1_31 Exclusive	0.00	-0.50	-0.62	-0.24	-0.11
tier1_31 Exclusive	EUR_PHC_cog_last_visit_wellderly_R4_21 Exclusive	0.00	-0.39	-0.50	-0.48	-0.14
EUR_PHC_cog_last_visit_wellderly_R4_21 Exclusive	Overlap	0.00	-0.46	-0.55	-0.46	-0.23
tier1_31 Exclusive	Overlap	0.01	25.64	10.19	27.68	2.32
Overlap	Exclusives	0.01	4.92	12.17	7.53	12.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_wellderly_R4_21 Exclusive	20	20	
tier1_31 Exclusive	30	29	MS4A
Overlap	1	1