Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R4_21	agegene_human	2.94e-01	2.00e-01	1.21e-01	8.28e-39
agegene_human	EUR_PHC_cog_last_visit_wellderly_R4_21	1.30e-01	6.00e-01	4.04e-03	1.72e-01



Evaluating how well EUR_PHC_cog_last_visit_wellderly_R4_21 genes are linked to agegene_human genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R4_21	agegene_human	0.71	-0.45	-1.26	-0.19	11.92
agegene_human	EUR_PHC_cog_last_visit_wellderly_R4_21	0.54	-1.58	-0.25	0.13	0.72

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R4_21	agegene_human	0.03	-0.54	-1.31	-0.19	9.23
agegene_human	EUR_PHC_cog_last_visit_wellderly_R4_21	0.00	-1.36	-0.47	0.11	-0.12

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_wellderly_R4_21	21	21	
agegene_human	307	305	TERC;TOP 1.00