Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R4_21	Kevin	5.92e-01	1.54e-01	5.90e-01	3.81e-01
Kevin	EUR_PHC_cog_last_visit_wellderly_R4_21	1.11e-01	7.39e-01	7.67e-01	5.13e-01



Evaluating how well EUR_PHC_cog_last_visit_wellderly_R4_21 genes are linked to Kevin genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R4_21	Kevin	0.53	-0.53	-2.07	-0.81	0.87
Kevin	EUR_PHC_cog_last_visit_wellderly_R4_21	0.50	-0.87	-0.44	-0.69	-0.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_wellderly_R4_21	Kevin	0.00	-0.40	-1.75	-0.71	-0.30
Kevin	EUR_PHC_cog_last_visit_wellderly_R4_21	0.00	-1.21	-0.18	-1.00	-0.30

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_wellderly_R4_21	21	21	
Kevin	80	77	CDKN2B-AS1;KN3KRP;LINC02049