Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	tier1_31	2.26e-07	7.25e-06	7.11e-07	2.26e-07
tier1_31 Exclusive	EUR_PHC_cog_last_visit_Impaired_R4_22	4.10e-01	4.31e-01	4.19e-01	4.13e-01
EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	tier1_31 Exclusive	4.74e-06	1.02e-04	5.95e-06	9.47e-07
tier1_31 Exclusive	EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	2.91e-01	7.26e-01	8.01e-01	7.55e-01
EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	Overlap	2.07e-03	2.76e-03	8.97e-03	1.18e-02
tier1_31 Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	5.36e-11	6.82e-11	1.14e-14	6.82e-11



Evaluating how well EUR_PHC_cog_last_visit_Impaired_R4_22 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	tier1_31	0.81	4.39	5.27	3.43	6.05
tier1_31 Exclusive	EUR_PHC_cog_last_visit_Impaired_R4_22	0.59	0.38	1.16	1.02	1.60
EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	tier1_31 Exclusive	0.80	4.32	4.96	3.04	5.03
tier1_31 Exclusive	EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	0.55	-0.14	0.78	0.07	0.66
EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	Overlap	0.95	2.20	3.03	2.10	2.14
tier1_31 Exclusive	Overlap	1.00	2.22	2.04	2.24	2.97
Overlap	Exclusives	0.80	5.35	7.62	3.19	6.75

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	tier1_31	0.01	12.14	13.26	4.21	13.31
tier1_31 Exclusive	EUR_PHC_cog_last_visit_Impaired_R4_22	0.02	38.99	27.43	40.62	41.82
EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	tier1_31 Exclusive	0.01	10.44	12.41	3.65	5.05
tier1_31 Exclusive	EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	0.00	7.92	10.93	5.17	9.29
EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	Overlap	0.00	8.76	2.13	5.00	1.96
tier1_31 Exclusive	Overlap	0.05	111.59	138.20	119.47	249.23
Overlap	Exclusives	0.08	21.64	189.49	23.49	80.12

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	20	20	
tier1_31 Exclusive	29	28	MS4A
Overlap	2	2