Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	agegene_human	1.59e-04	8.82e-04	7.63e-11	1.80e-44
agegene_human Exclusive	EUR_PHC_cog_last_visit_Impaired_R4_22	1.83e-01	9.38e-01	1.66e-03	3.38e-01
EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	agegene_human Exclusive	2.66e-04	8.12e-04	3.74e-07	7.27e-45
agegene_human Exclusive	EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	7.11e-01	9.48e-01	3.49e-03	6.09e-01
EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	Overlap	2.96e-04	9.85e-05	6.50e-03	1.48e-03
agegene_human Exclusive	Overlap	9.85e-05	5.17e-01	9.85e-05	5.91e-04
Overlap	Exclusives	2.29e-01	4.35e-19	9.49e-110	5.59e-85



Evaluating how well EUR_PHC_cog_last_visit_Impaired_R4_22 genes are linked to agegene_human genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	agegene_human	0.74	0.88	3.62	1.13	13.69
agegene_human Exclusive	EUR_PHC_cog_last_visit_Impaired_R4_22	0.60	1.56	0.71	0.82	1.68
EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	agegene_human Exclusive	0.74	1.02	3.39	0.86	14.29
agegene_human Exclusive	EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	0.57	1.71	0.57	0.58	1.13
EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	Overlap	0.97	2.21	5.04	2.07	2.49
agegene_human Exclusive	Overlap	0.99	1.61	0.90	1.31	2.87
Overlap	Exclusives	0.81	0.03	10.17	1.43	20.42

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	agegene_human	0.03	1.22	7.67	1.69	17.40
agegene_human Exclusive	EUR_PHC_cog_last_visit_Impaired_R4_22	0.00	4.55	1.24	3.04	1.38
EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	agegene_human Exclusive	0.03	1.39	5.81	1.31	14.56
agegene_human Exclusive	EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	0.00	3.03	1.15	1.41	0.49
EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	Overlap	0.00	6.21	23.99	5.39	0.33
agegene_human Exclusive	Overlap	0.00	4.31	-1.05	2.36	12.35
Overlap	Exclusives	0.05	0.61	20.33	1.89	36.93

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_PHC_cog_last_visit_Impaired_R4_22 Exclusive	20	20	
agegene_human Exclusive	305	303	TOP 1.00;TERC
Overlap	2	2