Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
welldery_R2_95	tier1_31	2.88e-03	1.80e-03	1.56e-03	1.39e-05
tier1_31	welldery_R2_95	1.53e-01	1.41e-01	1.33e-01	3.08e-01



Evaluating how well welldery_R2_95 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
welldery_R2_95	tier1_31	0.76	1.85	3.66	2.09	4.42
tier1_31	welldery_R2_95	0.54	1.07	1.63	1.69	1.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
welldery_R2_95	tier1_31	0.00	1.43	3.37	1.75	4.16
tier1_31	welldery_R2_95	0.01	2.42	1.38	2.75	0.87

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
welldery_R2_95	95	93	TRIM39-RPP21;RFPL2
tier1_31	31	30	MS4A