Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) welldery_R2_54 tier1_31 3.39e-03 3.69e-04 2.68e-04 4.61e-06 tier1_31 welldery_R2_54 6.41e-01 2.03e-01 2.72e-01 3.26e-01 Evaluating how well welldery_R2_54 genes are linked to tier1_31 genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) welldery_R2_54 tier1_31 0.77 1.87 4.28 3.01 4.36 tier1_31 welldery_R2_54 0.55 0.86 1.20 1.20 1.40 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) welldery_R2_54 tier1_31 0.00 2.80 5.49 4.56 7.40 tier1_31 welldery_R2_54 0.00 2.67 1.83 4.31 0.66 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes welldery_R2_54 54 52 TRIM39-RPP21;RFPL2 tier1_31 31 30 MS4A