Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
welldery_R2_54	tier1_31	3.39e-03	3.69e-04	2.68e-04	4.61e-06
tier1_31	welldery_R2_54	6.41e-01	2.03e-01	2.72e-01	3.26e-01



Evaluating how well welldery_R2_54 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
welldery_R2_54	tier1_31	0.77	1.87	4.28	3.01	4.36
tier1_31	welldery_R2_54	0.55	0.86	1.20	1.20	1.40

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
welldery_R2_54	tier1_31	0.00	2.80	5.49	4.56	7.40
tier1_31	welldery_R2_54	0.00	2.67	1.83	4.31	0.66

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
welldery_R2_54	54	52	TRIM39-RPP21;RFPL2
tier1_31	31	30	MS4A