Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_ac1	KW_Aging_Genes	7.69e-01	1.20e-01	8.27e-02	3.14e-02
KW_Aging_Genes	wellderly_ac1	7.97e-01	3.45e-01	6.19e-02	9.61e-06



Evaluating how well wellderly_ac1 genes are linked to KW_Aging_Genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_ac1	KW_Aging_Genes	0.63	2.08	2.18	2.83	2.45
KW_Aging_Genes	wellderly_ac1	0.63	0.55	1.88	0.85	5.64

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_ac1	KW_Aging_Genes	0.00	0.42	0.09	0.77	1.66
KW_Aging_Genes	wellderly_ac1	0.01	0.75	2.92	0.98	5.75

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_ac1	137	137	
KW_Aging_Genes	30	30