Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_ac1	tier1_AD	9.02e-01	1.77e-01	1.11e-01	8.24e-03
tier1_AD	wellderly_ac1	8.32e-01	1.60e-02	4.66e-03	2.47e-09



Evaluating how well wellderly_ac1 genes are linked to tier1_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_ac1	tier1_AD	0.67	0.97	1.47	1.10	2.96
tier1_AD	wellderly_ac1	0.65	1.14	3.58	1.29	6.21

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_ac1	tier1_AD	0.00	-0.07	0.28	0.37	0.75
tier1_AD	wellderly_ac1	0.01	0.07	1.10	0.43	5.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_ac1	137	137	
tier1_AD	31	30	MS4A